May 2009

TABLE OF CONTENTS

API Characterization Services: Does Your Molecule Need Tutoring?
Derrek G. Hennecke, MBA, continues with part 2 of this 6-part series covering unique strategies for building lasting competitive advantages. 

Transdermal Delivery: Successful, Sustained-Release Using a Selective Charged Barrier Membrane

Emma A. Durand discusses a new approach to enhancing the transport of drugs across the stratum corneum that uses a selective barrier membrane to prevent the inadvertent transport of drugs by diffusion, even at elevated skin temperatures.

 

Development & Characterization of Inhaled Formulations for Systemic Drug Delivery

M.W. Samaha, PhD; H.A. El-Maradny, PhD; D.M. Ragab, PhD; and F.M. El Khawas, PhD; determine the effects of formulation excipients and physical characteristics of inhalation drug particles on their aerosolization properties to optimize their respirable fractions, establishing which formulations could be the most appropriate for pulmonary protein delivery.

 

Rethinking Biopharmaceuticals With Albumin Fusion Technology

Dave Mead, PhD, and Ruth McDermott, PhD, MBA, claim their company’s new technology can be useful in overcoming the challenges in delivering and manufacturing protein therapeutics.

 

Light Microscopic Determination of Particle Size Distribution in an Aqueous Gel

Philo Morse, MS, and Andrew Loxley, PhD, describe two methods to determine the particle size distribution of suspended API in a viscous aqueous gel that involve a minimum of sample preparation and can analyze samples with broad particle size distributions.

 

Dynamic Powder Characterization for DPI Formulations

Robert Price, PhD, and Tim Freeman review the way powders behave in DPIs and examine the dynamic and bulk powder properties that help to explain the mechanisms that dominate performance.

 

A New Process Producing Biodegradable Microspheres of Peptide Drugs: Suspension – Encapsulation

Cherng-ju Kim, PhD, describes a method of successfully preparing drug-containing biodegradable microspheres using the suspension-encapsulation method.

 

Symyx Technologies: Turning R&D Into ROI

Executive Summary: Richard Boehner, President of Symyx High Productivity Research, speaks about the latest trends in R&D within the life sciences industry (including the increase in outsourcing) to help organizations in better respond to the rapid changes taking place in the industry.

 

Emerging Trends in Outsourcing Protein & Peptide Manufacturing

Contributor Cindy H. Dubin discovers that CMOs are experiencing a business boon in this ailing economy thanks to the expertise they bring to Specialty Pharmas interested in protein and peptide manufacturing.

 

Driving Winning Partnerships: Principles & Practices

Matt Siefert, MBA, explains, using real-life strategies, how open communication is of critical importance for the success of an alliance.

 

DEPARTMENTS

 

Market News & Trends

 

Advanced Delivery Devices

Drug Delivery of Sensitive Biopharmaceuticals With Prefilled Syringes

 

Technology Showcase

 

External Delivery

Up to My Blank in Alligators: A Short Story of the Youngster & the Unprofessional

 

COVER

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