issues
March 2010
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The Fight Within Pharma
Derek G. Hennecke, MBA, concludes this 6-part series covering unique strategies for building lasting competitive advantages.
Polymer-Based Pharmaceutical Compounds
Bill Martineau, MBA, believes synthetic polymers, spurred by ongoing advances in resins and related processing technologies, are expected to broaden applications as drug delivery compounds.
Investigation of the Influence of Tablet Shape, Geometry & Film Coating on Drug Release From HPMC ER Matrices
Shahrzad Missaghi, PhD; Piyush Patel, MPharm; Sandip B. Tiwari, PhD; Thomas P. Farrell, PhD; and Ali R. Rajabi-Siahboomi, PhD; indicate that tablet design offers opportunities to refine release profiles, rebrand existing products, and create distinctive formulations, allowing greater benefits from ER oral dosage forms.
A Binary Immunoliposomal System Directed to Cx43-Positive Glioma Cells
V.P. Chekhonin, MD, PhD; V.P. Baklaushev, MD, PhD; O.I. Gurina, MD, PhD; et al evaluate the Cx43-positive cell selectivity of a binary system based on biotinylated MAb to Е2 domain of Сх43 and PEGylated liposomes with streptavidin (SAv) for C6 glioma cell culture in vivo.
Significantly Reduced Drug-Apparent Solubility Using a Micronization Process
Wei-Guo Dai, PhD; Liang C. Dong, PhD; Shu Li, Crystal Pollock-Dove, and Zhengyu Deng, PhD; report study results that clearly demonstrate the significant influences of different milling processes on compound solubility.
The AtuPLEX Technology for Therapeutic siRNA Delivery in Oncology
Ansgar Santel, PhD; Oliver Keil, PhD; Klaus Giese, PhD; and Jörg Kaufmann, PhD; summarize the clinical development of Atu027 for oncology and the underlying AtuPLEX (siRNA-lipoplex) technology.
3M Drug Delivery Systems: Continuing Innovation in a Changing Global Marketplace
Drug Delivery Executive: Mr. James Vaughan, the division’s Vice President & General Manager, discusses his company’s approach to the changing climate in the pharmaceutical industry and how 3M helps its customers bring their products to market.
Enavail: Particle Engineering Solutions for Drug Delivery Challenges
Drug Delivery Executive: Dr. Brian Windsor, Enavail’s President, explains how the company is effecting change in drug delivery development through its innovative technologies.
GLC Market Trends: Clinical Trial Outsourcing is a Win-Win for Pharma & CROs
Contributor Cindy H. Dubin learned from two of the leading CROs that better communication between them and their Specialty Pharma clients leads to a more successful drug development process.
Pharmacogenomics & Drugs: Now it’s Personal!
Frost & Sullivan Analyst Katheryn Symank explains how increasing use of pharmacogenomics in both drug discovery and clinical applications are changing our approach to medicine.
DEPARTMENTS
Market News & Trends
Advanced Delivery Devices
Human Factors Engineering: Improving Medical Device Design to Ensure Safe, User-Friendly Medical Devices
Combination Update
Newly Proposed Good Manufacturing Practices
Technology Showcase
External Delivery
Crossing Over to Management