issues
January 2010
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Product Development, Expectations & the Real World
Josef Bossart, PhD, explains how failing to meet business expectations damages credibility that can lead to lost opportunities, lost funding, and in worst case situations, a failed business.
Magnetofection: Magnetically Assisted & Targeted Nucleic Acids Delivery
Cédric Sapet, PhD; Loïc Le Gourrierec, PhD; Ulrike Schillinger, PhD; Olga Mykhaylyk, PhD; Séverine Augier, Christian Plank, PhD; and Olivier Zelphati, PhD; believe magnetofection can overcome drug delivery barriers by using both advantages of physical methods and synthetic vectors.
Modified-Release Hydrogel Matrix Tablets & Encapsulated Multi-Particulate Beads: A Formulator’s Perspective
Jaidev S. Tantry, PhD, Gloria A. Rood, PhD, and Sarah M. Betterman provide an overview of these technologies and discuss the options available to the formulator to develop an effective oral modified-release drug product.
Intranasal Delivery of Stem Cells & Genetically Engineered Cells to the Brain
William H. Frey II, PhD, and Lusine Danielyan, MD, indicate non-invasive intranasal delivery, previously used to bypass the BBB and target therapeutic proteins, polynucleotides, and small molecules to the CNS, has now been shown to deliver stem cells and genetically engineered cells to the brain in rodents and could revolutionize the way cell-based therapy is conducted for CNS disorders.
Controlled Release of Highly Water-Soluble Drugs From the SQZgel Oral Drug Delivey System
Kirk P. Andriano, PhD, reviews SQZgel and demonstrates it to be a promising oral delivery system for once-a-day or twice-a-day dosing regimens of water-soluble drugs.
On the Rise: Drug Delivery Companies You Should Know About
In this annual feature, Contributor Cindy H. Dubin examines several lesser-known, but worth knowing, innovators to find out more about their technologies and how they are meeting the unique needs in the industry today.
Highly Bioavailable Nasal Calcitonin – Potential for Expanded Use in Analgesia
Edward T. Maggio, PhD; Elias Meezan, PhD; DKS Ghambeer, MD; and Dennis J. Pillion, PhD; believe the advent of highly effective and non-irritating alkylsaccharide absorption-enhancement agents affords a practical opportunity to reconsider the broader use of calcitonin as a highly effective non-invasive analgesic for a variety of bone pain indications.
Laser Diffraction Particle Size Analysis: A Powerful Tool for Rapidly Screening Nebulizer Formulations
Lei Mao, PhD; David Wilcox, and Paul Kippax, PhD; review the use of laser diffraction particle size analysis, a technique complementary to CI, to rapidly screen nebulizer formulations with directly comparable results.
Unilife Medical Solutions: Emerging Strong in the Prefilled Safety Syringes Market
Drug Delivery Executive: Mr. Alan Shortall, CEO of Unilife, discuss his company’s current business model, what makes them unique, and their approach to the future.
Elan Drug Technologies: Still the World Leader After 40 Years!
Drug Delivery Executive: Mr. Peter Thornton, Senior Vice President, Head of Product, Technology, and Business Development, talks about Elan’s 40 years of growth and future plans to continue leading the drug delivery market.
DEPARTMENTS
Market News & Trends
Excipient Update
A Competitive Comparison of an ODT Excipient System
Technology Showcase
External Delivery
Some Turnarounds Are Purely Academic