Dinesh Haswani, PhD; John Nagel, MBA; Derek Moe, PhD; and Ehab Hamed, PhD; say formulations developed using OraGuard technology provide overlapping resistance against various tampering methods, such as crushing and ingestion, chewing, small-volume extract
DRUG DEVICES – The Rise of the Bolus Injector – A New Device Class Enabling Long-Duration Subcutaneous Administration of Large-Dose Volume Biologics
Alan Shortall reviews Unilife’s bolus injectors for large-dose volume injectable therapies, and how Unilife is already working with a number of companies to customize each device to address the specific needs of a series of pipeline and approved molecules.
DRUG DELIVERY – Hyaluronic Acid: An Ideal Ingredient for Slow-Release Formulations for Osteoarthritis Treatment
Morten J. Maltesen, PhD; and Ole M. Dall, MSc; believe that in addition to its physiological and biological effects in the joints, HA exhibits significant structural and rheological properties that make it an attractive carrier for drug delivery applications.
In this exclusive Drug Development & Delivery annual report, handheld injection experts provide their thoughts about the various factors backing the adoption of the devices including ease of use, pain-free delivery, and differentiation for product line extensions.
DRUG DESIGN – Fragment-Based Drug Design: Delivering Drugs That Hit Multiple targets, Leveraging Insights From Systems Biology
David Pompliano, PhD, believes the next generation of pharmaceuticals will have to hit more than one target simultaneously in order to fully exploit the knowledge gained from systems biology, and currently, the most effective strategy to achieve this rational design goal is computational fragment-based drug design (CFBDD).
Jean C. Sung, PhD, says that while delivery of drugs via first-generation inhaled drug systems provides great advantages over oral or intravenous delivery, these systems also have inherent limitations, creating a tremendous opportunity for next-generation inhaled delivery platforms.
EXECUTIVE INTERVIEW – Caisson Biotech: Innovatio in Drug Delivery Using a Naturally Occurring Sugar Molecule
Thomas Harlan, CEO of Caisson, discusses how his company is improving the quality and delivery of numerous medications, making life easier for patients, and offering new ways for companies to enhance their drug pipeline.
Jonathan Wilkins, PhD, and Iain Simpson believe a fast and effective approach to a better injection device design is a novel combination of mathematical modeling on a desktop PC, supported with complementary experimental data.
DRUG DELIVERY – Recent Developments in Microneedle Technology for Transdermal Drug Delivery & Vaccination
Mikolaj Milewski and Amitava Mitra highlight some of the recent advances in the field of microneedle-mediated transdermal drug delivery and vaccination, including summaries of preclinical pharmacokinetic data and a brief overview of clinical studies, encompassing the time period from 2010 to present day.
SPECIAL FEATURE – Transdermal, Topical & Subcutaneous: Non-Invasive Delivery to Expand Product Line Extensions
Contributor Cindy H. Dubin asked delivery system providers and contract developers and manufacturers to describe their products and service offerings in their respective areas of expertise and how they are changing the overall landscape of the transdermal, topical, and subcutaneous markets.
EXCLUSIVE ONLINE CONTENT
One of the most critical early steps in the development of novel drug delivery systems is to demonstrate convincing proof-of-concept. The dilemma is that while pharma companies can be interested in….
Nemera recently announced it has entered into an agreement to acquire Copernicus, which specializes in the development and manufacturing of injection devices…
Lonza recently announced a $93-million investment in its Capsules and Health Ingredients (CHI) Division, a dosage form delivery partner to the biopharma and health nutrition industry…..
WEBINAR SERIES ALERT – Learn About Complex Parenteral Drug Delivery From Evonik Industry Experts – Free Oct-Nov Webinar Series
As a global CDMO leader for advanced drug delivery, Evonik invites you to join us for a webinar series on parenteral drug delivery. More than a dozen technical experts from Evonik will review….
Diane Paskiet says the relationship between pharmaceutical products and CC/DD is best managed through a rich science-based approach that factors in potential risk and is adapted early in the development process.