Formulation Development
EXCIPIENT COMPACTION STUDY - Developing a Reliable Controlled-Release Polymer Using a Compaction Simulator
Gopeshkumar Singh, MS, and Ajit Bhagat provide study results showing that through polymer chemistry, it is viable to effectively manufacture matrix tablets via a simple direct compression method; and Hypromellose has impressive compatibility at various compression forces.
Ascendia Pharmaceuticals Named to Inc. 5000 List of America’s Fastest-Growing Private Companies for Third Consecutive Year
Ascendia Pharmaceuticals recently announced it has been named to the prestigious Inc. 5000 rankings of the fastest growing privately-owned companies in the United States for…
DRUG DISCOVERY - Getting the Most From a DNA-Encoded Library Screen
Matthew A. Clark, PhD, says despite this high level of interest, there remains variable understanding of how to maximize the potential of a DEL screen, and shares his company’s approach to DEL screening and how its partners get the most from this powerful technology.
PLATFORM TECHNOLOGY - The Evolution of Cancer Vaccines: Moving Beyond Failure & a New Era for Cancer Treatment
Jeremy R. Graff, PhD, says new studies show promising data with the use of mRNA-based vaccines and the injection of nanoparticles into regional lymph nodes to achieve disease stabilization. This has led to a potentially groundbreaking era of therapeutic cancer vaccines thanks to discoveries in identifying truncal targets, targeting tumor neoantigens and, notably, developing improved delivery technologies that stimulate a robust, targeted, and persistent immune response.
NANOPARTICLE ENGINEERING - Lighting the Way to a Patient-Centric Future
Christopher Worrall, PhD, discusses how nanoparticle engineering technologies could help improve compliance and patient outcomes, for both small-molecule and biological drugs, and how nanotechnology can help facilitate a shift toward more patient-centric medicine.
TOP SPRAY GRANULATION - POLYOX™: Producing Lightweight Metformin Hydrochloride Extended-Release Tablets for Patient Adherence & Cost-Effective Manufacturing
Atul Lohade, PhD, Vinay Muley, and Tejas Gunjikar, PhD, explain how understanding the challenges associated with developing smaller extended-release tablets, and the excipient-based solutions to these challenges, will empower formulators to develop robust, stable drug formulations with high patient adherence while cutting manufacturing costs.
Alexion, AstraZeneca Rare Disease to Acquire LogicBio Therapeutics to Accelerate Growth in Genomic Medicine
LogicBio Therapeutics, Inc. recently announced it has entered into a definitive agreement under which AstraZeneca Rare Disease will acquire LogicBio. The proposed acquisition…
Biogen & Denali Therapeutics Announce Initiation of Phase 3 LIGHTHOUSE Study in Parkinson’s Disease Associated With LRRK2 Pathogenic Mutations
Biogen Inc. and Denali Therapeutics Inc. recently announced dosing has commenced in the global Phase 3 LIGHTHOUSE study to evaluate the efficacy and safety profile…
Zealand Pharma Announces Positive Results from Phase 3 Trial of Glepaglutide in Patients With Short Bowel Syndrome (EASE 1)
Zealand Pharma A/S recently announced positive topline results from the pivotal Phase 3 trial of glepaglutide, a long-acting GLP-2 analogue designed for once or twice…
ON-DEMAND WEBINAR - CMC Strategy to Take Bispecifics From DNA to IND in 13 Months* by Lonza
Lonza has applied it’s 35 years of CMC experience in Biologics to develop an end-to-end comprehensive DS/DP DNA to IND strategy in 13 months. This presentation….
Spectradyne Launches New ARC Particle Analyzer
Spectradyne recently launched its second-generation product, the ARC particle analyzer. Spectradyne’s ARC is a ground-breaking technology for analyzing biological nanoparticles in complex….
NJIT Researchers Unlock a New Method for Testing Protein-Based Drugs
New Jersey Institute of Technology researchers have unveiled a new lab technique they say represents a “paradigm shift” in how pharmaceutical laboratories test and produce…
BD Launches State-of-the-Art Cloud Software Solution to Streamline Flow Cytometry Research
BD (Becton, Dickinson and Company) recently launched BD® Research Cloud, a cloud-based software solution designed to streamline the flow cytometry workflow to enable higher….
Cornerstone Pharmaceuticals Initiates Phase 1 Trial of CPI-613 in Combination With Chemoradiation for the Treatment of Advanced Pancreatic Cancer
Cornerstone Pharmaceuticals, Inc. recently announced the initiation of a Phase 1 clinical trial evaluating CPI-613 (devimistat) in combination with chemoradiation for the treatment of advanced…
Cara Therapeutics Announces Difelikefalin Injection NDA Has Been Submitted in Japan
Cara Therapeutics, Inc. recently announced its licensing partner Maruishi Pharmaceutical Co., Ltd. submitted a New Drug Application (NDA) in Japan for approval of difelikefalin for…
KemPharm Announces Positive Topline Data from Phase 1 Clinical Trial Evaluating Cardiovascular Safety of Serdexmethylphenidate
KemPharm, Inc. recently announced topline data from its exploratory Phase 1 clinical trial confirming the relative cardiovascular effects and pharmacokinetics of serdexmethylphenidate (SDX) compared to…
Actylis Debuts, Signaling the Creation of an Integrated Global Specialty Ingredients Manufacturing & Sourcing Powerhouse
Actylis, a leading global manufacturer and sourcing expert of critical raw materials and performance ingredients for the life sciences and specialty chemicals markets, recently made its debut…..
Wheeler Bio Announces President & Chief Operating Officer
Wheeler Bio, a new CDMO specializing in the cell line development, process development, and small batch clinical production of antibodies, has announced the appointment of….
Bora Pharmaceuticals Partners With TaiRx to Manufacture Breakthrough Anti-Cancer Drug
Bora Pharmaceutical Laboratories Inc., a division of Bora Pharmaceuticals, has partnered with TaiRx, Inc., a premier Taiwan new drug development company, to manufacture a novel anti-cancer drug, CVM-1118. ….
Clearmind Applies for Patent to Treat Obesity & Metabolic Syndrome
Clearmind Medicine Inc. recently announced it has filed a provisional patent application related to metabolic syndromes including obesity. The patent application is another result of…
