Zosano Pharma & Asahi Kasei Pharma Enter Agreement for Transdermal Patch for Up to $132.5 Million
Zosano Pharma, Inc. and Asahi Kasei Pharma Corporation (AKP) recently announced they have entered into a long-term strategic collaboration for the development, commercialization, and supply of a weekly transdermal patch formulation of Teribone (teriparatide acetate), AKP’s formulation of human parathyroid hormone (human PTH 1-34), for the treatment of osteoporosis patients with a high risk of fracture.
Under the terms of the agreement, AKP has received exclusive rights to develop and commercialize the transdermal patch formulation of Teribone in
The agreement was signed on February 22, 2011, although AKP and Zosano agreed not to disclose the agreement until the subcutaneous injection form of Teribone for osteoporosis patients was approved in
“AKP and Zosano have joined their world-class and complementary assets to create what we believe have the opportunity to be the best-in-class product for bone growth in severe osteoporosis patients,” said Gail Schulze, Chief Executive Officer of Zosano. “We believe this relationship will provide a product with superior fracture reduction and enhanced patient compliance compared to the currently available PTH injectables to those patients with a high degree of unmet need.”
As part of the agreement, AKP has paid Zosano $7.5 million in up-front consideration. In addition, AKP will pay over $25 million in milestone payments related to development, regulatory, and launch accomplishments. Zosano will receive revenue-based royalties based on sales of the microprojection patch formulation of Teribone in the Asian territories, as well as reimbursement for all development and manufacturing costs. AKP is committing significant additional financial and technical resources toward the development of the patch for the treatment of osteoporosis in the Asian territories, and expects to begin clinical trials in
“Our partnership with Zosano reinforces AKP’s commitment to seek out innovative products that complement our existing portfolio in orthopedics and address significant unmet medical needs in
Teribone is a human parathyroid hormone preparation that facilitates bone formation. A Phase III clinical trial in
Zosano’s ZP Patch Technology is based on microprojections that deliver therapeutic compounds (including peptides, proteins, small molecules, and vaccines) to the skin’s outer layer and provide rapid and efficient systemic drug delivery in a convenient, needle-free, and pain-free system. Zosano’s ZP Patch Technology is the most clinically validated microneedle technology in the world, having been tested in more than 450 patients with over 20,000 patches successfully applied to humans in Phase I and Phase II clinical studies.
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