WHITEPAPER – Revolutionizing Small Molecule API Production: Unveiling the Impact of Fermentation as a Sustainable Solution


While large molecules continue to advance in drug development pipelines, small molecule Active Pharmaceutical Ingredients (APIs) still retain their historical dominance among new drug applications (NDAs). However, the last few years have seen the lines blurring between traditional chemical synthesis of small molecule APIs and biofermentation of large molecules, as production of small molecule drug substances in recombinant hosts gains ground. This is due to recent technological developments which have led to significant growth in the suitability of fermentation for a myriad of applications. In this white paper, the impact of the evolution of synthetic biology and supporting technologies on modern fermentation practices will be discussed.

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