New Opportunities for Oral Sustained Release Formulations With Polyvinyl Alcohol
Achieving the appropriate release kinetics for an active pharmaceutical ingredient (API) is essential to ensure success of the therapeutic. For example, for sustained release formulations, a consistent API dose over a prolonged period ensures that levels in the blood plasma remain within the therapeutic window. This is important, as the API levels must be maintained higher than the minimum effective concentration and below the maximum tolerated dose. The combined effect is a safe and efficacious dosage form, which provides a therapeutic effect while avoiding toxic side effects. For certain medications, sustained release can allow a larger amount of API to be taken in a single dose,
which can reduce the number of total daily doses required. Ultimately, sustained release can combine a more optimized and safe dosage regime with patient convenience, leading to increased adherence. Click here to download/view the entire white paper.
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