PolyTherics & MacroGenics Extend ThioBridge Collaboration
PolyTherics Limited recently announced an extension to its ThioBridge antibody drug conjugate (ADC) collaboration with MacroGenics Inc.
PolyTherics has developed ThioBridge for site-specific conjugation of cytotoxic payloads to antibodies to provide more stable and less heterogeneous ADCs. MacroGenics has two antibody technology platforms, a Dual-Affinity Re-Targeting (DART) bi-specific platform, in which a single recombinant molecule is able to target two different antigens, and Fc-optimized antibodies with improved effector function.
The collaboration was extended following the successful outcome of a research programme undertaken in 2013 under a Research Collaboration and Option Agreement, in which ThioBridge was used to conjugate a cytotoxic payload to a range of DART antibodies. MacroGenics and PolyTherics will collaborate in the application of its ThioBridge technology to a number of product candidates derived from MacroGenics’ antibody platforms. MacroGenics has an option to licence the ThioBridge technology for the development of these product candidates, and PolyTherics would receive development milestones and a single-digit percentage royalty on sales of any ThioBridge ADC derived from this collaboration.
“We are pleased with the success of our initial work with MacroGenics’ antibodies, and their extension of the collaboration to a wider range of antibodies and payloads endorses their support for the versatility of ThioBridge and its use to produce better ADCs,” said John Burt, CEO of PolyTherics.
PolyTherics provides technology solutions to enable the development of better biopharmaceuticals and offers a portfolio of proprietary and complementary technologies and services to address key needs in biopharmaceutical development. Its portfolio of services and technologies includes proprietary site-specific conjugation technologies and novel polymers for optimizing the therapeutic properties of biopharmaceuticals and through its Cambridge, UK-based subsidiary, Antitope, services for protein immunogenicity assessment and antibody and protein re-engineering technologies are delivered. For more information, visit www.polytherics.com.
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