PolyPid Unveils a Long-Acting GLP-1 Receptor Agonists Delivery Platform Targeting the Diabetes & Weight Loss Market
PolyPid Ltd. recently unveiled its long-acting GLP-1 receptor agonists (glucagon-like peptide-1 RA) delivery platform that aims to subcutaneously release GLP-1 RA for approximately 60 days, significantly longer than current weekly injection regimens. The platform releases GLP-1 in a linear way, overcoming the burst release seen with the current weekly delivered molecules. This discovery has the potential to significantly expand PolyPid’s offering to a market which is projected to reach $100 billion by 2030.
“This recent discovery represents a potential paradigm shift in GLP-1 therapy delivery that could transform patient care in the rapidly expanding diabetes and weight management markets,” said Dikla Czaczkes Akselbrad, Chief Executive Officer of PolyPid. “By harnessing our proprietary prolonged-release technology, we aim to provide patients with consistent, therapeutic levels of GLP-1 for approximately 60 days with a single administration, potentially eliminating the need for weekly injections. This new pipeline discovery potentially marks a significant advancement in improving medication adherence and patient outcomes, addressing a critical gap in the treatment of obesity and type 2 diabetes chronic diseases.”
PolyPid’s proprietary technology is a sophisticated drug delivery system consisting of a polymer-lipid based matrix that creates a protected drug reservoir. This unique matrix architecture enables controlled and continuous drug delivery in the body over a prolonged time (weeks to months) in a single application. The technology has been clinically validated in over 1,000 patients including in two Phase 3 trials with no major safety concern.
PolyPid Ltd. (Nasdaq: PYPD) is a late-stage biopharma company aiming to improve surgical outcomes. Through locally administered, controlled, prolonged-release therapeutics, PolyPid’s proprietary PLEX (Polymer-Lipid Encapsulation matriX) technology pairs with Active Pharmaceutical Ingredients (APIs), enabling precise delivery of drugs at optimal release rates over durations ranging from several days to months. Following positive phase 3 results of D-PLEX100, PolyPid’s lead product candidate, for the prevention of abdominal colorectal surgical site infections, New Drug Application (NDA) submission is expected in early 2026. In addition, the company is currently in preclinical stages to test the efficacy of OncoPLEX for the treatment of solid tumors, beginning with glioblastoma. For more information, visit http://www.polypid.com.
Total Page Views: 277
