issues

March 2016

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COVER

CLOUD COMPUTING – Using Quantum Molecular Design & Cloud Computing to Improve the Accuracy & Success Probability of Drug Discovery

Ed Addison and Shahar Keinan, PhD, explain how cloud computing combined with the continued influence of Moore's Law has provided an unprecedented opportunity to apply inexpensive high-performance computing to drug discovery.

FEATURES

LYOPHILIZATION – The Key to Creating Acceptable & Effective Fast-Dissolving Oral Formulations

Leon Grother says multiple products are on the market made using a controlled lyophilization process. The fast-dissolving characteristics it can impart have enabled the demands of several challenging patient populations to be met with formulations of important medicines that work well for them.

DISSOLUTION TESTING – Exploring the Link Between Particle Size & Dissolution Behavior for OINDPs

Paul Kippax, PhD; Deborah Huck-Jones, PhD; et al review current trends in dissolution testing within the context of understanding particle size, which impacts clinical studies and ultimately generic submissions.

MANAGEMENT INSIGHT – Why I Sold Xcelience: The Non-Linear Path of Decision-Making

Derek Hennecke explains that he sold his company to Capsugel, and some of you may be wondering did he sell out? He shares with you some of the thought process that brought him to this momentous and very emotional decision, as well as some of the lessons he learned.

PULMONARY DELIVERY – Afrezza – Another Lesson for Drug Delivery Professionals?

Josef Bossart, PhD, believes Mannkind’s recent announcement that Sanofi has decided to return the marketing rights for Afrezza may not exactly be history repeating itself, but it certainly feels as though it rhymes.

SPECIAL FEATURE – Advancements in Drug Delivery Technologies Tackle Solubility & Bioavailability Challenges

Contributor Cindy H. Dubin speaks with several innovator companies to learn more about the latest advances in drug delivery to address the challenging issues of solubility and bioavailability today

NEXT-GENERATION SEQUENCING – NGS: Uniformity Across the Block

Andrew Birnie, PhD, explores how innovations in instruments, such as the Eco 48 real-time qPCR system (PCRmax), deliver exceptional uniformity, actively improving the reliability and productivity of the working laboratory.

EXECUTIVE INTERVIEW – Cardax Inc: Delivering Nature-Identical Astaxanthin to the Market

David G. Watumull, President and CEO of Cardax, Inc, discusses the company’s plans to create a new platform for products in the consumer health and pharmaceutical markets based on the delivery of nature-identical astaxanthin.

PACKAGING SOLUTIONS – New Deep-Drawn Alufoil Container Solves Crucial Packaging Issues for Vital Pharmaceutical Products

Georg Buchinger and Cora Helberg show how the adoption of aluminum containers for pharmaceutical products is a natural evolution of a technology used by packaging leaders since the 1990s, and an ideal prophylactic measure for the growing needs of demanding pharma customers.

EXTERNAL DELIVERY – 5 Topics Your Board Needs to Discuss Immediately

Last week, this magazine’s Executive Director, Dan Marino, asked me to comment on an article titled 5 Topics Your Board Needs to Discuss Immediately by Patricia Lenkov that was posted..

CLOUD COMPUTING – Using Quantum Molecular Design & Cloud Computing to Improve the Accuracy & Success Probability of Drug Discovery

Ed Addison and Shahar Keinan, PhD, explain how cloud computing combined with the continued influence of Moore's Law has provided an unprecedented opportunity to apply inexpensive high-performance computing to drug discovery.

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