Biogen Renews License With Absorption Systems

Absorption Systems, a world leader in novel test systems for drug transporters, recently announced the renewal of a technology licensing deal with Biogen. After years of contract testing by Absorption Systems using MDR1-MDCK cells, Biogen licensed the technology associated with the test system from Absorption Systems in October 2015 and is renewing the license for another year. This cell line is stably transfected with the human MDR1 gene, which codes for a protein known as multi-drug resistance protein or P-glycoprotein (P-gp).

Drug transporters, such as P-gp have received increasing attention from drug regulatory bodies, such as the US FDA and the European Medicines Agency (EMA) because of their importance in drug absorption, excretion, and safety. This human MDR1 assay system enables Biogen to test new drug candidates for interactions with P-gp, which is involved in resistance of tumors to anticancer drugs, drug distribution and clearance, and drug-drug interactions (DDIs). As a result of P-gp, drugs that show promising efficacy in the lab may be inaccessible to the organ of interest during clinical trials. MDR1-MDCK cells express P-gp at a high level and allow users to predict human outcomes during early stage preclinical testing of their drug candidates.

Absorption Systems is well known for its rigorous quality control programs and relentless tracking of cell line performance over time by using its proprietary CellPort Analytics software. These factors, along with the immense equity in terms of historical data on Biogen’s compounds, made a compelling argument for the company to renew the license from Absorption Systems.

Absorption Systems uses GxP-compatible biological services and testing platforms to assist pharmaceutical, biotechnology, and medical device companies in identifying and overcoming absorption, distribution, metabolism, excretion, and toxicity (ADMET) barriers in the development of drugs, biologics, and medical devices. The company’s mission is to develop innovative GxP biology research tools, and provide exemplary service, to accurately predict human outcomes or to explain unanticipated human outcomes when they occur. The CellPort Technologies platform, a suite of human cell-based test systems for drug transporter characterization, exemplifies Absorption Systems’ commitment to innovation and excellence in GxP biology. Absorption Systems has facilities near Philadelphia, PA, and in San Diego, CA, and Panama City, Panama, and serves customers throughout the world. For more information, visit