WHITEPAPER – Long-Acting Injectable Nanoparticle Formulations
Long acting injectable (LAI) formulations have been the subject of continued interest in the recent past due, in part, to their longer systemic circulation requiring less frequent dosing of drugs. Less frequent administration, as illustrated in Figure 1, make LAIs more attractive from patient compliance perspectives. While delivering the extended release, LAIs can reduce toxicity and enhance the efficacy and safety of drugs. Other benefits also include the accessibility of medicines at nominal cost for underserved patient populations for treatment of life-threatening diseases likeHIV, as compared to long-term implants.
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