Vectura Signs Development Agreement With Kinaset Therapeutics

Vectura Group plc recently announced it has signed a global outlicense and development agreement with Kinaset Therapeutics Inc. for the development and commercialization of VR588, a preclinical novel inhaled pan-JAK inhibitor for the prevention and treatment of severe asthma.

Pan-JAK inhibitors have been developed and tested in clinical trials, approved and commercialized for many different indications but mainly for the treatment of chronic inflammatory conditions associated with an overactive immune response. VR588 was previously developed by Vectura as part of its former speciality pharma pipeline. This agreement provides an opportunity for Vectura to realize value from its historical research and investment in VR588, whilst expanding its CDMO development services portfolio by supporting the product’s further development with Kinaset.

Under the terms of the agreement, Kinaset’s lead development program will be an inhaled product for severe asthma delivered through a dry powder device. Vectura will provide fee for service development expertise to Kinaset to formulate this product to support Phase 1 studies, and ultimately through to commercialization. Vectura will grant a license to Kinaset to develop and commercialize VR588, in return for development and sales milestones, and future royalties. Kinaset may pursue VR588 products in other indications and Vectura would be entitled to milestones and royalties on future products.

Will Downie, Chief Executive Officer of Vectura, said “We look forward to working closely with Kinaset to support their development of this product, with the potential to bring a new treatment option to asthma patients in the future. This agreement is in line with our CDMO strategy to leverage our deep expertise, built through years of research in inhaled drug development, to help customers bring new inhaled therapies to market.”

Vectura is a provider of innovative inhaled drug delivery services that enable partners to bring their medicines to patients. With differentiated proprietary technology and pharmaceutical development expertise, Vectura is one of the few companies globally with the device, formulation and development capabilities to deliver a broad range of complex inhaled therapies. Vectura has eleven key inhaled and eleven non-inhaled products marketed by partners with global royalty streams, and a diverse partnered portfolio of drugs in clinical development. Our partners include Hikma, Novartis, Sandoz (a division of Novartis AG), Mundipharma, Kyorin, GSK, Bayer, Chiesi, Almirall, and Tianjin KingYork. For more information, visit

Kinaset is a Boston-based therapeutics company focused on the advancement of novel drugs in areas of unmet medical needs. Kinaset Therapeutics intend to develop novel therapeutics that can positively impact people affected by intractable diseases, including severe asthma. Their novel lead asset and experienced team combine a potentially best in class approach to treating severe asthma with a group of dedicated drug development experts, working to bring the therapy forward. For more information, visit