Shape Therapeutics Enters Strategic Research Collaboration With Roche to Advance Breakthrough AAV-Based RNA Editing Technology for Neuroscience & Rare Disease Indications
Shape Therapeutics Inc. recently announced a multi-target strategic collaboration and license agreement with Roche. Through this partnership Shape will apply its proprietary RNA editing platform RNAfix and potentially leverage its AAVid technology platform for next-generation tissue-specific adeno-associated viruses (AAVs) for the development of gene therapy for certain targets in the areas of Alzheimer’s disease, Parkinson’s disease, and rare diseases.
During the course of the partnership, Shape will conduct preclinical research to identify and deliver development candidates discovered by its AI-powered platforms RNAfix and, potentially, AAVid. Roche will be responsible for the development and worldwide commercialization of any potential products resulting from the collaboration.
“Our mission at Shape is to unlock the next breakthrough in RNA technologies in the gene therapy space across a wide range of therapeutic areas,” said Francois Vigneault, PhD, Co-founder and Chief Executive Officer of Shape. “The relationship with Roche quickly centered on a common desire to tackle some of the world’s most challenging diseases by accelerating the development of breakthrough technologies towards the clinic.”
“We are excited by the disruptive potential of Shape’s RNA-editing approach based on nature’s own mechanism for specific base editing. This new collaboration is also perfectly aligned with our broader efforts across the Roche Group to unlock the full potential of gene therapy,” said James Sabry, Head of Roche Pharma Partnering. “We look forward to working with Shape to create novel treatment options for neuroscience and rare disease indications.”
Under the terms of the agreement, Shape is eligible to receive an initial payment as well as development, regulatory, and sales milestone payments, potentially exceeding $3 billion in aggregate value. Shape is also eligible to receive tiered royalties on future sales of products resulting from the collaboration.
Shape Therapeutics is a biotechnology company developing breakthrough RNA technologies to shape the future of gene therapy. The Shape gene therapy platform is composed of RNAskip, RNAfix, and RNAswap payload technologies, next-generation tissue-specific AAVid delivery technology, and SquareBio, a solution for scalable gene therapy manufacturing based on industrialization of human stable cell lines. At the core of these technologies is the Shape AI engine, where data drives decisions today to enable tomorrow’s gene therapies. Shape is committed to data-driven scientific advancement, passionate people, and a mission of providing lifelong cures to patients. For more information, visit shapetx.com.
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