Plus Therapeutics, Inc. (Nasdaq: PSTV) (the “Company”), a clinical-stage pharmaceutical company developing targeted radiotherapeutics for central nervous system (CNS) cancers, today announces that it has signed an agreement to enter into a strategic partnership with Ephemeral Technologies (“Ephemeral”) to deliver a unique AI execution platform for CNS oncology. The AI execution platform is designed to integrate, organize, and derive actionable intelligence from longitudinal therapeutic, diagnostic and bioinformatic data sets generated across Plus’ CNS oncology technology programs.

“Plus is building a CNS oncology platform to integrate across our therapeutics, diagnostics and bioinformatics data sets,” said Marc Hedrick, M.D., Plus Therapeutics President and Chief Executive Officer. “Our partnership with Ephemeral and its expertise in deploying artificial intelligence brings industry-proven engineering and advanced AI capabilities to the most challenging area of oncology. This partnership is intended to help further position Plus as a leader in CNS oncology and accomplish our mission of improving survival for patients with the most devastating cancers.”

Ephemeral was founded by the former co-heads of Palantir Technologies’ U.S. healthcare business. Ephemeral was launched to bring AI solutions to life sciences to accelerate drug development.

Plus and Ephemeral believe the combination of multi-modal, longitudinal data with generative AI reasoning and agentic workflows will create both near- and long-term value for shareholders. Beginning in 2026, Plus anticipates tangible improvements in both laboratory and clinical operating efficiency and workflows. Beyond 2026, Plus intends to increasingly use artificial intelligence for fully integrated operational workflows, operational decision support, translational and treatment response analytics, patient stratification, precision oncology initiatives, pharmaceutical collaborations and real-world evidence initiatives.

“Ephemeral was founded to help companies like Plus align AI to real scientific and operational execution to more quickly deliver better medicines to patients,” said Drew Goldstein, Ephemeral Co-Founder and Co-Chief Executive Officer. “Plus’ unique positioning and data sets in CNS oncology represents an ideal opportunity for Ephemeral, and we are proud to leverage our technology to support Plus’ mission to help patients with CNS cancers.”

Under the agreement, Plus Therapeutics and Ephemeral will assess and implement AI-enabled data infrastructure to support the integration, organization, and analysis of complex CNS oncology data sets generated through the Company’s therapeutic and diagnostic workflows. No financial terms of the agreement were disclosed.

Additional information is available at https://www.ephemeral.now.