MilliporeSigma Signs Exclusive Agreement With BioDuro
MilliporeSigma has signed a supply and OEM agreement with BioDuro, LLC, on exclusive terms, for worldwide distribution of AISF ([4-(Acetylamino)phenyl]-ImidodiSulfuryl diFluoride), a convenient, shelf-stable, crystalline reagent for the synthesis of fluorosulfates and sulfamoyl fluorides. AISF was developed through a research collaboration with Pfizer Inc.
While fluorosulfates have immense potential applications, from chemical biology to polymer chemistry, the currently utilized method of synthesis relies on the use of sulfuryl fluoride gas. Because sulfuryl fluoride gas is a colorless, odorless, and toxic gas that requires specialized equipment and additional safety precautions when using, this potentially valuable functional group has previously not been fully evaluated or broadly adopted.
Three key attributes were sought for a solid reagent that could be an alternative to sulfuryl fluoride gas: 1) the reagent must demonstrate comparable or improved reactivity to sulfuryl fluoride gas; (2) it must be a crystalline, shelf-stable and easily manipulated solid and (3) it must be readily accessible for manufacturing on a large scale from commercially available starting materials.
AISF is a stable, crystalline solid that allows for a user-friendly fluorosulfonation reaction set-up, and it has excellent substrate scope. The reagent is easily manipulated in an open atmosphere and is stable at ambient temperature as either a solid or in solution, over a prolonged period of time. MilliporeSigma will be BioDuro’s exclusive, global OEM partner of AISF.
BioDuro is a full-service provider for integrated drug discovery and development, including discovery support, API synthesis and optimization, formulation development, and cGMP manufacture of drug products. From drug substance to drug product, discovery to development, small molecule or biologics, BioDuro is your partner for accelerating drug discovery and development and improving efficiency in establishing drug candidate success. For more information, visit www.bioduro.com.
MilliporeSigma is your trusted global partner for the development and supply of commercial quantities of functionalized PEGs (polyethylene glycols). Those in turn, are essential for your PEGylated therapeutic proteins for drug delivery. Our offerings include high-purity materials for use in investigational products in every phase of clinical development and in commercialized products. We understand that you care about rapid and cost-effective time to market. Therefore, setting the right quality attributes for the functionalized PEG is crucial for the manufacturing and stability of your PEGylated product — we can help you get it right. And during the marketing phase, expertise in life-cycle management and regulatory affairs can help you safeguard your compliance. For more information, visit www.emdmillipore.com.
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