Macomics & Ono Pharmaceutical Partner to Discover & Develop Macrophage-Targeting Antibody Therapy for Cancer Treatment

Macomics Ltd recently announced it has entered into a worldwide drug discovery collaboration agreement with Ono Pharmaceutical Co., Ltd. to develop new immuno-oncology antibody drugs against a novel macrophage target of interest in cancer.

Under the terms of the agreement, Macomics will identify and characterize antibody candidates against the novel target of interest using its ENIGMAC macrophage drug discovery platform. Ono will have an exclusive option to license global rights to the candidates for further development and commercialization. Macomics will receive an up-front payment, R&D funding, and success-based milestone payments, as well as tiered royalties based on global net sales.

Macomics is exploiting the potential of macrophage-based approaches to develop novel precision medicines to target disease specific macrophage biology. Macomics’ ENIGMAC macrophage drug discovery platform integrates large volume human data sets, custom cell models, and proprietary human macrophage genome editing capability to discover novel targets and unlock disease specific target biology. Macrophages (TAMs) are often the most abundant immune cell many types of cancer and modulating TAMs can enhance the body’s ability to fight cancer.

Toichi Takino, Senior Executive Officer/Executive Director, Discovery & Research of Ono, said “Targeting macrophages in immune-oncology is emerging as an exciting area with significant opportunity to deliver novel therapeutics to improve cancer outcomes and to change the lives of patients with cancer. Macomics has demonstrated the power of its macrophage platform and drug discovery approach and we are delighted to partner with them on taking this novel target discovery program forwards.”

Stephen Myatt, CEO of Macomics, added “This global collaboration with Ono is a testament to our strong program portfolio, and the unique enablement offered by our ENIGMAC discovery platform, and our world class R&D team. Ono is a leader in immuno-oncology and we are delighted to have a partner in Ono who brings the complementary skills necessary to succeed in this therapeutic area.”

Macomics Ltd is an immuno-oncology company with world-leading expertise in macrophage biology, developing precision medicines to modulate macrophages for the treatment of cancer. The company is progressing a diversified portfolio of therapies targeting disease specific tumor-associated macrophages (TAMs) toward the clinic. Its ENIGMAC macrophage drug discovery platform enables identification and validation of novel macrophage therapeutic targets and is based on its deep understanding of macrophage biology.

The company was co-founded in 2020 by Prof. Jeffrey Pollard and Dr. Luca Cassetta, University of Edinburgh, internationally recognised leaders in macrophage biology. It has R&D and office facilities in Edinburgh and Cambridge, UK and is backed by Epidarex Capital, Scottish Enterprise, LifeLink Ventures and Caribou Property Limited. For more information, visit