May 2011

TABLE OF CONTENTS

Drug Pricing 101

Derek G. Hennecke, MBA, continues with part 2 of his newest 6-part series on how not to blow the recovery!

 

Two Questions for Drug Delivery

Josef Bossart, PhD, raises debate about Drug Delivery’s role as a set of formulation technologies, a complement to the pharmaceutical industry toolbox, or as a business sector that develops technologies and products that provide for better therapeutic outcomes.

 

Vaccines ““ The Sustainable Blockbuster Business

Frost & Sullivan Analyst Barath Shankar Subramanian believes that while the small molecule business continues to struggle to keep up to pace with the growth of the global healthcare market, vaccines continue to remain one of the most stable and reliable sources of growth for biopharmaceutical companies.

 

Pulmonary Peptide Delivery With a Pharmacokinetic Profile That Closely Mimics Endogenous Peptide Secretion

Andrea Leone-Bay, PhD; Robert A. Baughman, PhD; Chad Smutney, and Joseph Kocinsky explain how peptides inhaled as dry powder Technosphere formulations are absorbed very rapidly, often resulting in pharmacokinetic profiles that mimic the endogenous hormone secretion characteristic of healthy individuals, enabling exogenous hormone administration that is aligned with normal human physiology.

 

Formulation & Evaluation of a Transdermal Patch Containing Fluconazole

Rakesh P. Patel, PhD; Chirag P. Patel, MPharm; Bhupendra G. Prajapati, MPharm; and Chaudhary Varsha, BPharm; develop a matrix-type transdermal therapeutic system containing fluconazole (FLZ) with different grades of hydroxy propyl methyl cellulose (HPMC) polymers.

 

Liquid-Filled & Multi-Phase Capsules: Overcoming Solubility, Reducing Costs & Improving Commercial Viability

Contributor Cindy H. Dubin speaks with liquid-filled and multi-phase capsule developers on how they are offering Pharma and Biotech line extensions to currently marketed products and the intellectual property protection that comes with it.

 

Colonic Delivery of Metronidazole Tablets Using a Double-Coating Technique 

Nitesh Shah, MPharm; Tejal Shah, MPharm, PhD; and Avani Amin, MPharm, PhD; develop a novel time- and pH-based drug delivery system for potential colonic delivery using multiple coatings of polymethacrylates, which may be ideal for chronic treatment of Crohn’s disease.

 

DBV Technologies: Pioneering the Safe Desensitization of Patients Suffering From Dangerous Food Allergies

Drug Delivery Executive: Pierre-Henri Benhamou, MD, Co-Founder & CEO of DBV Technologies, discusses the VIASKIN platform and how it will whet the appetite of Big Pharma to lead an entirely new pharma franchise as big as statins or vaccines.

 

Recent Therapeutic Advances Targeting Toll-Like Receptors

Alcide Barberis, PhD, provides an overview of the products under development as well as the main functions of TLRs and their relevance to the treatment of, for example, infection, cancer, and autoimmune diseases.

 

Particle Sciences & Horiba Instruments: Providing Clients a Total Solution

Executive Summary: Robert Lee, PhD, VP of Pharmaceuticals and Quality, Particle Sciences, and Michael Pohl, PhD, VP, Horiba Instruments, Inc. discuss their recent strategic alliance to provide their clients with the most up-to-date physical characterization tools with operational expertise in a fully GLP/GMP-compliant setting.

 

DEPARTMENTS

 

Market News & Trends

 

Excipient Update

Investigating the Influence of a Film-Forming Formulation on Oxygen & Moisture Vapor Transmission Rates

 

Technology & Services Showcase

 

External Delivery

The Escalator Test

COVER

FEATURES