Ionizable Lipids in LNPs: A Selection Guide
Lipid nanoparticles (LNPs) are a promising approach for the delivery of nucleic acid cargoes for an untold number of health applications. One of the current interests in LNP research is the identification of strategies that achieve targeted delivery of the nucleic acid cargo. The lipid composition, especially the ionizable cationic lipid component, is one strategy that can be used to achieve targeted LNP delivery. This selection guide helps researchers find candidate ionizable cationic lipids for their application by target or cargo type:
- View lipids for organ-specific targeting: liver, lung, spleen, and lymph node
- View lipids for cell-specific targeting: CAR T cells, tumors, and immune cells
- View lipids by cargo type: mRNA, siRNA, CRISPR-Cas9, and more
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