Accelerating Tablet Technology Transfer Using Compaction Simulation
This case study describes how compaction simulation allowed our customer to investigate the causes of tabletability loss during dry granulation and confirm the potential impact of over-lubrication during scale-up. The results established a defined processing window for roller compaction and tableting, enabling the team to de-risk technology transfer, conserve material, and support efficient scale-up.
Tabletability loss during scale-up can compromise manufacturing performance and introduce risk during technology transfer. In this case study, compaction simulation conducted through the OSDPredict™ platform was applied to identify the root causes of tabletability issues and define a robust processing window. This approach supported reliable scale-up and technology transfer for the customer facing this challenge.
Using the OSDPredict™ platform, scientists were able to:
- Identify the root causes of tabletability loss during scale-up
- Evaluate material and process parameters impacting performance
- Define a robust processing window for manufacturing
- Enable more reliable and efficient technology transfer processes
Key outcomes of compaction simulation
- Improved tabletability and manufacturing consistency
- Reduced risk during scale-up and technology transfer
- Defined optimal processing parameters for robust production
- Increased confidence in commercial manufacturing readiness
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