CDMO Pfizer CentreOne Launches Green-Chemistry Progesterone API

CDMO Pfizer CentreOne Launches Green-Chemistry Progesterone API

Pfizer CentreOne recently announced the introduction of Enviero progesterone into the API marketplace. Enviero progesterone is produced by a first-of-its-kind progesterone synthesis developed by Pfizer that reduces waste, greenhouse gas emissions, and use of hazardous solvents. Results include cutting the carbon footprint of the progesterone manufacturing process by more than 70% and eliminating the use of metal catalysts. Pfizer CentreOne is a global contract manufacturing organization embedded within Pfizer Inc. and a leading supplier of steroid and hormone APIs and intermediates.

“Enviero green-chemistry progesterone represents a step change in progesterone API synthesis,” said Greg Scanlon, API Business Lead for Pfizer CentreOne. “And it’s in keeping with Pfizer’s commitment to reduce its impact on the environment.” Developed over 12 years, Enviero (En-VI-ro) progesterone is manufactured via a proprietary biocatalytic process based on plant sterols. Scanlon continued, “We are pleased to offer Enviero progesterone to customers looking for a reliable supply of high-quality progesterone for their medicines.”

While new to Pfizer CentreOne customers, Enviero progesterone has been used by Pfizer as an intermediate in the manufacture of its own medications for the past 4 years. More than 500 metric tons have been manufactured to date for internal use.

The compound is manufactured exclusively in the United States at Pfizer’s Kalamazoo, MI, facility. As with all Pfizer CentreOne APIs, all processing steps for Enviero progesterone are performed under Pfizer’s stringent quality management system, and the compound is backed by technical and regulatory support for the life of the product.

Enviero progesterone is the first API to be launched from Pfizer CentreOne’s green-chemistry program. According to the US Environmental Protection Agency, “Green chemistry is the design of chemical products and processes that reduce or eliminate the use or generation of hazardous substances.” Green chemistry is applied at the process level – in this case, API synthesis – to minimize waste and pollution upfront.

For a primer on green chemistry, visit www.epa.gov/greenchemistry/basics-green-chemistry. For more on Enviero progesterone, visit https://www.pfizercentreone.com/apis-intermediates/enviero%E2%84%A2-green-chemistry-progesterone. For information on Pfizer’s Environmental Sustainability Program, visit www.pfizer.com/purpose/environmental-sustainability/green-journey.

Pfizer CentreOne is a global CDMO embedded within Pfizer. We focus on custom API synthesis, sterile injectable fill-finish and highly potent oral solid dose; and are a leading supplier of steroid and hormone APIs and intermediates. For more than 40 years, we’ve manufactured complex compounds for our biopharmaceutical partners, guiding their drugs safely from development through commercialization. For more information, visit www.pfizercentreone.com. Please contact Kristen Berg, Communications Manager, Pfizer CentreOne, kristen.berg@pfizer.com, 1-224-212-5466.