Aptar Pharma Twister® Chosen for Asthma Therapy

Louveciennes, France – Aptar Pharma, a global solution provider of innovative and proven aerosol, injection and spray delivery systems for biotech, healthcare and pharma products has partnered with Shanghai Sine Promod Pharmaceutical Co., Ltd. to develop and launch its new Budesonide DPI (Dry Powder Inhaler), which uses Aptar Pharma’s novel, user-friendly and cost-effective Twister^® Dry Powder Inhaler.

The First Drug Product Marketed With Twister^®

Budesonide DPI is designed for maintenance therapy in the treatment of asthma. Budesonide DPI is one of the first drug products manufactured locally and marketed in China. This cost-effective drug product incorporates Aptar Pharma’s Twister technology. Budesonide DPI contains an inhaled corticosteroid for the treatment of asthma in adults and children age six and over. The product is marketed in two versions, one version containing 30 capsules and the other, 60 capsules. Each capsule consists of 200 μg of budesonide blended with lactose monohydrate as the carrier.

Courtesy of Aptar Pharma

Constant Growth in the Asthma Treatment Market

The World Health Organization (WHO) estimates that approximately 235 million people worldwide suffer from asthma, with over 30 million in China alone. Due mainly to population growth in Chinese cities, increased air pollution is becoming a major cause of respiratory diseases. The Chinese Asthma and COPD market is growing rapidly, with a CAGR of 22.5% over the past five years.

Key Benefits of Aptar Pharma’s Twister^®

Twister is a new capsule-based DPI, designed and developed by a multidisciplinary technical team based at Aptar Pharma’s Centre of Excellence in Le Vaudreuil, France to specifically address unmet medical needs in fast-growing markets.

Twister has a simple and robust design with few components, making it cost-effective for asthma and COPD treatments, and has been tested and validated with a number of different dry powder drug formulations.

Twister is designed to be patient-friendly and easy to use, allowing patients easy access to their medication in three simple steps: insert, twist and inhale. To help improve patient compliance with the prescribed treatment, Twister is transparent, allowing the capsule and powder to be seen in the device as they are administered. In addition to these visual cues, the patient is also guided by audible feedback during inhalation.

“Shanghai Sine Promod Pharmaceutical Co., Ltd is one of Aptar Pharma’s key customers in China. We are particularly proud to have supported their Budesonide DPI program through the development and commercialization of Twister, manufactured locally in our Suzhou facility. This is a very important milestone for Aptar Pharma China,” stated Mrs. Yan Jiang, Vice President Northeast Asia for Aptar Pharma.

About Aptar Pharma

Aptar Pharma is part of the AptarGroup, Inc. family of companies, along with Aptar Beauty + Home and Aptar Food + Beverage. The company creates innovative drug delivery systems that meet the evolving needs of biotechnology, healthcare, and pharmaceutical companies around the world. It provides customers with a wide range of delivery technologies and analytical services backed by decades of proven expertise.

AptarGroup, Inc. (NYSE: ATR) is headquartered in Crystal Lake, IL, with manufacturing facilities in North America, Europe, Asia, and South America. For more information, visit www.aptar.com/pharma.

About Shanghai Sine Promod Pharmaceutical Co., Ltd

Shanghai Sine Promod Pharmaceutical Co., Ltd., was established in 1994, and specializes in cardiovascular, anti-inflammatory and respiratory drugs. A total of 30 products have been launched in the Chinese market, covering 28 provinces and municipalities.

Press Contacts

Elisa Eschylle, Events and Press Relations Manager

Tel: +33 (0)1 39 17 20 41

E-mail: elisa.eschylle@aptar.com

Marion Baschet Vernet, Press Attaché

Tel: +33 (0)6 22 17 08 96

E-mail: mbvernet@gmail.com

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