Quotient Clinical & Capsugel Announce Collaboration

Quotient Clinical and Capsugel recently announced a collaboration to enable the rapid development and clinical assessment of lipid-based formulations. Together, the companies will use their technology and expertise to address the drug delivery challenges of poorly soluble molecules with limited oral bioavailability.

The collaboration integrates Quotient’s RapidFACT real time clinical manufacture and testing service with Capsugel’s lipid-based formulation expertise and manufacturing capability. With up to 70% of the industry’s development pipeline consisting of molecules with poor solubility, the collaboration will fast track the effective clinical evaluation of lipid-based drug delivery systems in man, whilst optimizing the drug product for downstream development. As part of the collaboration, Quotient will utilize Capsugel’s CFS Liquid Capsule Filling and Sealing technology at its facility in Nottingham and will be able to access the formulation expertise in Capsugel’s Development Centre in Strasbourg.

“The collaboration with Capsugel will help our customers address prevalent drug delivery challenges for poorly soluble compounds in a more effective way. It will further empower our RapidFACT service by ensuring that selected drug products can be rapidly scaled up and transitioned into downstream development, further reducing timelines to critical development milestones,” said Mark Egerton, Managing Director of Quotient Clinical.

“Our expertise with poorly soluble drugs includes a proprietary predictive modeling technology based on an extensive database of lipid formulations that allows us to find the best formulas quickly,” added Keith Hutchison, Senior Vice President of R&D at Capsugel. “We also have a deep knowledge of capsules and our Licaps liquid filling and sealing technology helps to speed up the development process. These are perfect complements to Quotient’s ability to accelerate the generation of human clinical data, and we look forward to offering the new service to our global customers.”

Quotient Clinical, part of Quotient Bioresearch, has over 20 years of experience delivering high-quality data to provide innovative early drug development solutions to pharmaceutical and biotechnology clients worldwide, including 17 of the top 20 pharmaceutical companies. For more information or to discuss your specific needs, contact clinical@quotientbioresearch.com or visit www.quotientbioresearch.com/clinical.

Capsugel is a global leader in innovative dosage forms and solutions for the healthcare industry. Offering a comprehensive array of products and services, from hard gelatin, liquid-filled, and vegetarian capsules, to innovative R&D equipment, Capsugel is at the forefront of drug delivery innovation providing support to customers from formulation to final production. Capsugel also specializes in the formulation, development, clinical, and commercial supply of liquid filled hard and soft shell capsules to the healthcare industry. For more information about Capsugel, visit www.capsugel.com.