Oncodesign & UCB Enter Strategic R&D Collaboration

Oncodesign recently announced it has entered into a research collaboration and exclusive license option with UCB. The collaboration will leverage the respective expertise of Oncodesign and UCB to bring innovative therapeutic solutions to patients suffering from neurodegenerative disorders. Oncodesign will apply its Nanocyclix technology on a kinase target selected by UCB with the aim of discovering potent and selective inhibitors that cross the blood brain barrier.

Oncodesign’s Nanocyclix technology is a proprietary medicinal chemistry platform based on small molecule macrocyclisation that gives access to potent and highly selective kinase inhibitors with attractive physicochemical and ADME properties. Oncodesign has identified Nanocyclix leads against a broad range of known and unexplored kinases with potential in different therapeutic areas and is engaged in multiple collaborations with pharmaceutical partners.

“This collaboration with UCB further establishes Oncodesign as a major player in the drug discovery field. It strengthens our strategy of early partnering with leading international pharmaceutical companies in fields outside of oncology. This, together with our internal focus on innovative programs against cancer, constitutes a strong basis for addressing major unmet needs in patients and value creation,” said Philippe Genne, PhD, Chairman and CEO of Oncodesign.

“We are very excited to partner with UCB for the first time on this exclusive research collaboration and license option in the field of neurodegenerative disorders, an area with high unmet needs for a large patient population. This new collaboration demonstrates the growing interest that the pharmaceutical industry has in our Nanocyclix technology. This allows us to discover innovative inhibitors for kinases that are otherwise difficult to address,” said Jan Hoflack, PhD, CSO and Head of Oncodesign’s discovery activities.

Under the terms of the agreement, UCB is granted an exclusive option to license the joint program (with worldwide development and commercialization rights), upon successfully reaching certain discovery milestones. Oncodesign is entitled to funding for the program’s research activities, and upon exercise of the license option, a program access fee and additional research, development, regulatory, and commercial milestone payments for the development of molecules in two or more indications, and tiered royalties on net sales.

Founded in 1995 and headed by Dr. Philippe Genne, Oncodesign is a pioneer in the preclinical assessment of anti-cancer therapies. Oncodesign’s mission consists of discovering effective therapies against cancer and other important diseases. Its scientific expertise in pharmacology, imaging, and medicinal chemistry, in addition to strong project management skills, support the company’s two strategic activities of experimentation and discovery. For more information, visit www.oncodesign.com.

UCB, Brussels, Belgium, is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases of the immune system or of the central nervous system. For more information, visit www.ucb.com.