Bio-Rad Laboratories, Inc. recently extended its range of recombinant monoclonal anti-idiotypic antibodies, with the introduction of eight antibodies specific to romosuzumab (Evenity), burosumab (Crysvita), ixekizumab (Taltz), elotuzumab (Empliciti), isatuximab (Sarclisa), nirsevimab (Beyfortus), and tremelimumab (Imjudo), and released a recombinant monoclonal anti-biotherapeutic antibody specific to dulaglutide (Trulicity). The Company has also launched its first anti-Fc mutation antibody range, targeting drugs containing YTE mutations.

Bio-Rad’s range of highly specific, high-affinity, non-animal derived antibodies are suitable for use in preclinical and clinical pharmacokinetic (PK) and anti-drug antibody (ADA) assays, supporting therapeutic drug monitoring for biologic and biosimilar products. The addition of an antibody specific to dulaglutide marks Bio-Rad’s first antibody against a GLP-1 receptor agonist drug.

The launch of the anti-Fc mutation antibody range now enables the selective detection of YTE-modified therapeutics via the recognition of YTE triple substitutions (M252Y, S254T, and T256E) in the Fc region of human IgG1 antibodies—a modification shown to extend antibody half-life compared to wild-type IgG. The ready-made antibodies are suitable for the development of PK bridging ELISAs to measure free drug concentration in serum.

“With over 350 antibodies of more than 50 different specificities, Bio-Rad’s leading portfolio of monoclonal anti-idiotypic antibodies offers researchers greater flexibility to develop selective, sensitive, and reliable bioanalytical assays,” said Hilary Mavor, Marketing Director, Life Science Group, Bio-Rad Laboratories. “The launch of our first anti-Fc mutation range alongside a new range of anti-biotherapeutic antibodies, including our first against a drug acting as a GLP-1 receptor agonist, marks a significant step beyond classical anti-IDs, underscoring how our technology is adaptable to any new drug format and our commitment to drive innovation across antibody drug discovery.”

Bio-Rad Laboratories, Inc. (NYSE: BIO and BIO.B) is a leader in developing, manufacturing, and marketing a broad range of products for the life science research and clinical diagnostics markets. Based in Hercules, California, Bio-Rad operates a global network of research, development, manufacturing, and sales operations with approximately 7,400 employees and $2.6 billion in revenues in 2025. Our customers include universities, research institutions, hospitals, and biopharmaceutical companies, as well as clinical, food safety and environmental quality laboratories. Together, we develop innovative, high-quality products that advance science and save lives. To learn more, visit bio-rad.com.