Cellevate Demonstrates Successful Scale-Up of its Cellevat3d Nanofiber Microcarriers for Biomanufacturing at Testa Center

Cellevate recently announced the successful scale-up of its ground-breaking Cellevat3d nanofiber microcarriers funded by Vinnova/STUNS Life Science. The study was performed at Testa Center in Uppsala, Sweden, in the 10-liter Xcellerex XDR-10 single-use stirred tank bioreactor (Cytiva).

The nanofiber-based Cellevat3d microcarriers represent a potential paradigm shift in bioprocessing. They have up to 60x the surface area of “traditional” carriers, creating a true three-dimensional cell culture environment, significantly increasing viable cell densities and viral vector yields in stirred tank reactors. Cellevate plans to launch Cellevat3d nanofiber microcarriers in early November 2024.

“Scaling up at Testa Center in 10 L stirred tank bioreactor with our new category of nanofiber-based cell culture systems, while maintaining all the cell culture parameters unchanged from lab scale, is a great achievement. The study also demonstrated the ease of use and ease of implementation in bioreactors, and our ability to meet industrial bioprocessing scale up demand. We have now added the last piece of the puzzle in securing the success of the global commercial launch of the world’s first nanofiber-based cell culture systems designed to boost viral vector productivity – the global commercial launch will occur on November 4 at BIO-Europe in Stockholm,” said Laura Chirica, CEO of Cellevate.

“We’re thrilled to have supported Cellevate in their recent 3-week project at Testa Center which utilized our XDR10 bioreactor to scale up mammalian adherent cells. It’s fantastic to see innovative biotech companies like Cellevate leveraging our facilities to push the boundaries of cell culture technology. We’re proud to play a part in fostering advancements that help accelerate novel biotherapies development and production,” added Jesper Hedberg, CEO, Testa Center.

 Cellevate is a Swedish biotech company developing proprietary nanofiber technology designed to unlock the next generation cell culture systems for cell and gene therapy and novel vaccines biomanufacturing. The core nanotechnology, Cellevat3d, is a sustainable, deep-tech innovation for the biopharmaceutical industry. The platform allows industrial-scale production of nanofiber microcarriers with unparalleled surface area for cell growth, reproducibility, customization, and scalability, which ultimately lead to an improved biomanufacturing productivity and process economy. Cellevat3d nanofiber-based cell culture products are designed as an integrated part of upstream bioprocess solutions, from laboratory to large-scale batch production. For more information, visit www.cellevate.com.

Testa Center is a Swedish non-profit, open access innovation hub for biological production, available for academic researchers, start-ups, SMEs and large industry. Clients go to Testa Center to access the bioproduction environment which includes industry standard, state-of-the-art equipment, infrastructure, and expertise. In Testa Center, innovation projects can organically build value through pilot testing for scalability/manufacturability, control or reduce risk before entering a GMP production, gain speed towards market and/or generate large amounts of material for research and development. For more information, visit www.testacenter.com.