Knopp Biosciences Completes Enrollment in Phase 2 Trial of Oral Dexpramipexole in Eosinophilic Asthma
Knopp Biosciences LLC recently announced the completion of enrollment in a Phase 2 trial of the oral small-molecule dexpramipexole in patients with moderate-to-severe eosinophilic asthma.
The multi-center Phase 2 trial is a randomized, double-blind, placebo-controlled study to evaluate the effects of three dose levels of oral dexpramipexole for 12 weeks. The primary endpoint is the change in peripheral blood eosinophil count. Secondary outcome measures include changes in pre-bronchodilator FEV1 and asthma control outcomes (ACQ-7 questionnaire) from baseline to week 12.
“We are pleased to complete enrollment in this Phase 2 trial and look forward to reporting top-line data early in 2021,” said Michael Bozik, MD, Chief Executive Officer of Knopp. “Knopp is committed to developing oral dexpramipexole as a targeted, eosinophil-depleting, pre-biologic treatment for patients with moderate-to-severe eosinophilic asthma. The benefit of eosinophil lowering as a therapeutic approach in asthma has been demonstrated by the success of injectable biologics in reducing asthma exacerbations, and dexpramipexole holds the potential to provide an effective oral alternative to these approved biologic treatments.”
Eosinophils are white-blood cells that play a central role in a number of debilitating diseases, including asthma, hypereosinophilic syndrome (HES), eosinophilic gastroenteritis, and atopic dermatitis. Knopp has previously reported the highly significant eosinophil-lowering effects of oral dexpramipexole in clinical trials, including in a Phase 2 clinical trial in HES.
More information on the Phase 2 asthma trial can be found under identifier NCT04046939 at clinicaltrials.gov.
Knopp Biosciences is a privately held drug discovery and development company focused on delivering breakthrough treatments for immunological and neurological diseases of high unmet need. Knopp’s clinical-stage oral small molecule, dexpramipexole, is in Phase 2 clinical trials in moderate-to-severe eosinophilic asthma. Knopp’s preclinical Kv7 platform is directed to small molecule treatments for developmental and epileptic encephalopathies, other rare epilepsies, neuropathic pain, and tinnitus. For more information, visit www.knoppbio.com.
Total Page Views: 1280
