Cayman Chemical
1180 East Ellsworth Road
Ann Arbor, MI 48108
T: (800) 364-9897
E: LNP Solutions From Cayman Chemical
W: www.caymanchem.com
LinkedIn: https://www.linkedin.com/company/cayman-chemical

Cayman Helps Make Research Possible

With extensive expertise in lipid chemistry, synthesis, and purification, Cayman Chemical supports biopharma and biotech companies advancing lipid nanoparticle-based therapies from early discovery through clinical development with industry-leading research tools and services.

Our portfolio includes an expansive collection of high-quality lipids for LNP formulation, including ionizable cationic lipids, helper lipids, sterol lipids, and PEGylated lipids. We also offer LipidLaunch™ research-ready LNPs and reagent kits for LNP discovery and provide in-house custom lipid synthesis, LNP formulation, screening, and CGMP lipid manufacturing services.

From R&D to GMP, Cayman Supports LNP Development

Cayman helps our clients reach important milestones in their LNP R&D with stand-alone services or a comprehensive LNP development program. Backed by an interdisciplinary team of scientists, Cayman offers on-site R&D facilities for LNP development, characterization, and screening.

Our experts can also help design and synthesize novel ionizable lipids to expand your intellectual property portfolio, and they have the foresight and in-house process development expertise to guide you toward scalable, CGMP lipid components from Cayman’s CGMP manufacturing facilities in Ann Arbor, Michigan. We work with you to develop the best experimental design within your budget constraints to provide high-quality data with prompt, professional communication and quick turnaround.

Cayman’s LNP Development Services

• Design & Planning – Discuss your project and goals with our scientists, who will help you determine the optimal lipid LNP components and experimental design for your cargo and tissue or cell type of interest.

• Component Sourcing
  – Cargo – Clients supply their own nucleic acid cargo, choose from one of several reporter options we offer, or     provide a sequence for outsourced custom synthesis.
  – Lipids– Select from more than 350 ready-made lipids for LNPs or rely on our chemical synthesis experts for    design and synthesis of custom lipids.

• Formulation – Microfluidic formulation using variable flow rates and lipid ratios for screening LNPs or bulk preparation of R&D-optimized LNPs.
• Characterization – Analysis of LNP and payload concentration, particle size, polydispersity index, pK_a, stability, aggregation, and encapsulation efficiency.
• Screening – Bioanalytical services for in vitro assessment of payload delivery and downstream biological effects.
  – Ready-made assays and custom assay development with high-throughput options available.
  – Flow cytometry and high-content imaging readout of reporter payload delivery and/or expression, effects on cell viability.
  – Cell-based, immunoassays, enzyme activity, reporter, mass spectrometry, ELISpot, and immunophenotyping assays to measure the impacts of therapeutic payload delivery.
  – BSL2+ cell culture for immortalized or primary cells.

• CGMP Lipid Manufacturing – Take your LNPs to the next phase of development with our GMP Division. Our US-based GMP team can optimize the manufacturing and scale-up of lipid components for your formulation, ensuring the highest quality lipids and smooth transition to your CDMO partner of choice.

Links to Our Recent Guides, App Notes, and Resources

Guide: ​Lipid Nanoparticle Formulation: Basic Concepts & Preparation Procedures

Guide: Tuning Ionizable Cationic Lipid Design for Efficacy and Safety

​App Note: mRNA Delivery to Activated Primary Human T Cells Using C14-4 Lipid Nanoparticles

App Note: Encapsulation and Transfection of RNA Using LipidLaunch™ SM-102 Lipid Nanoparticles (Loadable)

Product Selection: LipidLaunch™ Research Tools for RNA Therapies

Discover the Latest LNP Research Tools & Resources From Cayman