Portal Instruments
190 5th St
Cambridge, MA 02141
T:  617-500-4348
E: partnering@portalinstruments.com
W: www.portalinstruments.com

Portal Instruments, a clinical-stage medical device company is developing a next- generation needle-free drug injection platform to transform the drug delivery experience for patients suffering from chronic diseases, such as ulcerative colitis, multiple sclerosis, rheumatoid arthritis, and psoriasis.

Today, patients suffering from many chronic conditions have access to biologic drugs that can greatly improve their well-being. Unfortunately, those drugs must often be self-injected via a needle and syringe, which can lead to patient anxiety and uncertainty. In some cases, patients may refuse treatment or skip injections and then might not be able to reach the outcomes that they wish.

Founded 4 years ago, Portal is looking to transform the experience for patients who are on these life-changing therapies. Originally developed in Ian Hunter’s lab at MIT, the Portal’s digital jet-injector is the only computer controlled needle-free drug delivery device technology available for clinical evaluation.

Previous jet-injectors used a mechanical means (eg, a high-powered spring, compressed air or gas cartridges like CO2 or Nitrogen) to generate, essentially, an “explosion” to inject the shot. These devices were loud, limited in delivery volume and often painful.

The Portal system, in contrast, uses a computer-controlled linear actuator that pressurizes the medication and injects it in a very fine jet. It can administer up to 1 mL of medication, is relatively quiet, fast, and automatically adapts to both viscosity and temperature of the medication. Studies have shown that patients perceive less pain and prefer the Portal Needle-free injector versus needle and syringe injections.1

A key part of the needle-free injection platform and patient experience are the companion digital tools to track injection timing and remind patients when it’s time for injection. The platform also has the potential to aggregate anonymized patient data on adherence, which can offer useful insights into treatments across a population set.

Portal Instruments is a Series B-funded medical device company and its Quality Management System is ISO 13485 certified.

Portal is looking to develop strong partnerships with all major biologics players seeking to gain an edge by offering their therapeutics fully integrated with an optimum delivery system.


  1. Kojic, N., et al. (2017). An Innovative Needle-free Injection System: Comparison to 1 ml Standard Subcutaneous Injection. AAPS PharmSciTech. doi: 10.1208/s12249-017-0779-0.