Micropore Technologies Inc.
2121 T.W. Alexander Drive, Suite 124
Morrisville, NC 27560  
T: (205) 639-3730

Micropore Technologies Limited 
Wilton Centre, Redcar, TS10 4RF, UK
T: +(44) 1642 438367
E:  camden.cutright@microporetech.com
W: www.microporetech.com
Twitter: @microporetech
LinkedIn: linkedin.com/company/micropore-technologies-ltd/

 

COMPANY DESCRIPTION

Micropore Technologies is a global process technology and service provider to the pharmaceutical industry featuring patented crossflow technology for the commercially scalable development of topical and sterile injectable drug products. Originally spun-out of Loughborough University’s internationally renowned chemical engineering department, the company’s global headquarters and technical center are located at Wilton Center, UK with offices and operations in the USA, India, South Korea & Japan supporting over a hundred clients and strategic partners.

OUR TECHNOLOGY & SERVICES

Micropore’s technology enables scalable formulation of mono-disperse microspheres, nanoparticles and emulsions. Our array of mixing devices are constructed to operate from early stage high throughput screening on the benchtop to fully integrated GMP manufacturing SKIDs. We offer best in class formulation consultation, in house discovery through preclinical feasibility trials, and process engineering services to supporting the development of commercial manufacturing processes.

Benefits of our gentle mixing approach include:

• Less set-up time, reduced raw materials, and maintenance cost
• Reproducibly uniform drug product
• Reduced use of expensive production additives
• Extremely energy efficient “green” production at all scales
• Higher product yields through less wastage
• No degradation of biologics or primary emulsions

Capabilities

• Early stage formulation development
• cGMP process consultation and scale-up from lab to commercial
• Pre-clinical batch production
• Aseptic cGMP compliance and validation support
• Particle sizing, shape, and encapsulation efficiency analysis
• Tech transfer of production hardware
• Global technical support and troubleshooting

For more information, visit: www.microporetech.com

VIDEOS

An Introduction to Micropore Technologies
A short two minute intro to Micropore’s unique particle engineering technology and the benefits it offers in formulating products across a wide range of sectors.

 

 

An Introduction to Micropore’s Crossflow Mixing Technology
A short explainer animation showing the principles behind Micropore’s membrane-based emulsification and encapsulation processes.

 

LINKS TO WHITE PAPERS

Phase Change Materials
Phase change materials (PCMs) allow the storage of large amounts of latent heat during phase transition. This white paper details their many benefits, the necessity of particle encapsulation in PCMs; and the benefits membrane-based particle formation.

 

 

 

Liposomes & Lipid Nanoparticles
This white paper describes the advantages of liposomes and lipid nano particles for the efficient delivery of therapeutic payloads in pharmaceuticals and the efficiencies that can be achieved using crossflow mixing to produce them.

 

 

 

Sustained Release PLGA Microspheres
Because of its unique properties PLGA is the most important polymer for drug encapsulation. This white paper describes how crossflow mixing devices, using the well-proven solvent evaporation method, are opening up new opportunities for PLGA-based products.

 

 

 

Hydrogels in Drug Delivery & Biomedical Engineering
Hydrogels possess the capability of protecting labile drugs from degradation, thus controlling their release properties. This white paper describes how crossflow mixing sidesteps the challenges of creating hydrogels with precise size control, forming perfectly spherical droplets in sizes less than 50 µm.

 

 

 

Core-Shell Coacervation in Drug Delivery
This white paper focuses on drug delivery using complex coacervation. Achieving an accurate target capsule size in an industrial setting can be a challenge. A preferred approach is a system, such as crossflow mixing, where the desired size characteristics can be defined in advance and the emulsion produced in a single pass.

 

 

 

Silica Particles
This white paper outlines how, through an improved continuous scalable sol-gel process, both micro- and mesoporous, near-monodispersed, spherical Mesoporous Silica Particles (MSPs), with high API load carrying potential, can be produced with a range of internal pores between 1 and 12 nm and an average surface area between 300 and 750 m2g-1.

 

 

 

API Crystallisation
Membrane crystallisation is a relatively new technique based on the use of a porous material as a semi-permeable barrier between two phases. This white paper describes how a membrane can be used to create supersaturation by solvent evaporation, antisolvent or reactant addition, and mixing with a colder solvent.