Genezen Laboratories
9900 Westpoint Dr, Suite 128
Indianapolis, IN 46256
T: 317.822.8330
E: info@genezenlabs.com
W: https://genezenlabs.com/about/
LinkedIn: https://www.linkedin.com/company/genezen-laboratories/
Twitter: @GenezenLabs https://twitter.com/GenezenLabs

 

Founded in Indianapolis in 2014, Genezen Laboratories is focused on supporting the demands of the current and future gene and cell therapy manufacturing market worldwide— making viral vector production accessible to both early-stage, growth-oriented companies and established industry leaders. Genezen offers early-phase process development, GMP vector production, and analytical testing services, building on the company’s expansive knowledge and experience in the industry and working with the nation’s leading institutions.

Genezen recently began construction on a 25,000 square foot initial phase of a larger cGMP-compliant lentiviral vector production facility in the Midwest which will include multiple cGMP production with capabilities for host cell expansion, host cell banking, and viral vector production via transient transfection and producer cell lines. The vector product will be aseptically filled into sterile bags providing the ideal presentation for use in cell therapy.

SERVICES

Process Development

  • Optimization at any stage for improved reproducibility and predictability
  • Commercial production planning
  • Producer cell line development
  • Suspension process adaptation
  • Assay development
  • Master cell bank and Master working cell bank generation

GMP Vector Production

  • GMP grade production of viral vectors
  • Adherent cell capability for up to 140L production
  • Proprietary suspension 293T cell line for up to 200L LVV
    production
  • Higher throughput and state-of-the-art equipment
  • Lentiviral vectors, Retroviral vectors, and AAV

Testing

  • Potency: Biological titers and transduction efficiency
  • Safety: Sterility, endotoxin, RCL testing (Extended and PCR based)
  • Identity: Vector insert stability
  • Stability: Vector stability studies
  • Residual testing: Benzonase, Host cell DNA and Plasmid DNA

Cell Manufacturing

  • Genetic modification (transduction)
  • Expansion, differentiation
  • Product cryopreservation
  • Enrichment or depletion of specific subsets
    • Stem cells and immune cells

 

Click here to view/download Genezen’s latest poster: Development of a Transfection-Based, Scalable, Serum-Free, Single-Use Suspension Platform for Manufacturing Lentiviral Vector