Posted Date: 1/27/2017

Domain Therapeutics & Merck Enter License & Collaboration Agreement

Domain Therapeutics recently announced that a collaboration and licensing agreement with Merck has been signed for the development of adenosine receptor antagonist drugs specifically designed for oncology and immuno-oncology.

The agreement will involve close collaboration between Merck and Domain Therapeutics to develop and test new agents targeting key adenosine receptors. Merck will support research activities and gain worldwide rights to Domain Therapeutics’ next generation of adenosine receptor inhibitors. Under the terms of the agreement, Domain will be eligible for more than €240 million in milestones, as well as undisclosed royalties.

“With its growing portfolio of immuno-oncology agents, Merck is the ideal partner to develop our adenosine programs,” said Pascal Neuville, CEO, Domain Therapeutics. “As a strong collaborator with a leading investigational checkpoint inhibitor, we are confident that through Merck, our programs will progress rapidly.”

Adenosine has been identified as a key component in resistance mechanisms for many tumors targeted by immune check-point inhibitors. While blocking certain adenosine receptors has been shown to increase the response to immune checkpoint inhibitors, antagonizing other adenosine receptors has also been shown to slow tumor progression.

"This new generation of adenosine receptor antagonists is an important addition to our immuno-oncology pipeline,” said Laszlo Radvanyi, Senior Vice President, Head of Research in Immuno-oncology at the Biopharma Business of Merck. “We plan to explore the promise of adenosine receptor antagonists and develop novel compounds to potentially use in new combination immunotherapies for cancer.”

Domain Therapeutics is a biopharmaceutical company based in Strasbourg, France, dedicated to the discovery and early development of small molecules targeting G protein-coupled receptors (GPCRs), one of the most important classes of drug targets. Domain Therapeutics identifies and develops new drug candidates, allosteric modulators and biased ligands through its innovative approach and distinctive technologies. The company provides access to its technologies through research and collaborative agreements and develops its own pipeline up to the stage of clinical candidate for major indications in the central nervous system and oncology. For more information, visit www.domaintherapeutics.com.

Related Taxonomy
Popularity:
This record has been viewed 885 times.


















- SHL


Click here to see the showcases


INTERPHEX
March 21-23
New York, NY

PDA Annual Meeting
April 3-5
Anaheim, CA

RDD (Respiratory Drug Delivery)
April 25-28
Nice, France

Pre-filled Syringes East Coast
April 26-27
Boston, MA


AAPS National Biotechnology Meeting
May 1-3
San Diego, CA

Innovation Networking Summit & Table-top Exhibition
May 4-5
Hilton Hotel, Parsippany, NJ

CPhI North America & Informex
May 16-18
2017 Philadelphia, PA

BIO 2017
June 19 - 22
San Diego, CA

Controlled Release Society Meeting
July 16-19 Boston, MA

CPhI Worldwide
October 24-26
Frankfurt, Germany

Universe of Prefilled Syringes & Injection Devices Europe
November 7-8
Nienna, Austria

AAPS
November 12-17
San Diego, CA

 



Copyright © 2017  Drug Development & Delivery All Rights Reserved. Privacy Policy / Terms and Conditions